Principal Scientist - Cell Culture Development

CSL

APAC, AU, Victoria, Melbourne, CSL Limited Melbourne Onsite Research Development & Sciences

About this role

We’re hiring a Principal Scientist in Cell Culture Development to join our team in Melbourne and play a key role in advancing biologics development.

This is a senior technical role where you’ll lead upstream process development, provide scientific direction, and help bring high-quality recombinant products from early development through to manufacturing readiness. You’ll work across platforms, collaborate cross-functionally, and contribute to impactful programs that support patient outcomes.

Your Responsibilities:

Provide scientific leadership and technical expertise in cell culture process development, optimisation, and scale-up
Design and execute upstream development strategies across high-throughput and mid-scale platforms
Lead and contribute to experimental planning, execution, and data interpretation with strong scientific rigour
Support process development across the full lifecycle from clone selection through to process characterisation
Guide and mentor team members, sharing expertise and building capability
Contribute to regulatory documentation and submissions
Collaborate with cross-functional teams to enable tech transfer and manufacturing readiness

Skills & Experience:

Postgraduate degree (MSc, PhD, MEng or equivalent) in a relevant field
Significant experience in cell culture process development (industry or advanced academic setting)
Proven track record working with recombinant protein production or similar systems
Comfortable working in cross-functional and multicultural teams

Experience with the following is highly regarded:

Mammalian cell culture, particularly CHO systems
Early- and late-stage process development
Media development and metabolic modelling
Process optimisation aligned to product quality attributes
Bioreactor scale-up and scale-down
Technology transfer or implementation of manufacturing processes

Why join us?

Work on cutting-edge biologics development
Influence key scientific and technical decisions
Collaborate with a highly skilled, multidisciplinary team
Be part of work that ultimately supports patient impact

If you’re a scientist who enjoys combining deep technical expertise with leadership and collaboration, we’d love to hear from you.

Applications Close on: June 3rd 2026

About CSL Behring

CSL Behring is a global biotherapeutics leader driven by our promise to save lives. Focused on serving patients’ needs by using the latest technologies, we discover, develop and deliver innovative therapies for people living with conditions in the immunology, hematology, cardiovascular and metabolic, respiratory, and transplant therapeutic areas. We use three strategic scientific platforms of plasma fractionation, recombinant protein technology, and cell and gene therapy to support continued innovation and continually refine ways in which products can address unmet medical needs and help patients lead full lives.

CSL Behring operates one of the world’s largest plasma collection networks, CSL Plasma. Our parent company, CSL, headquartered in Melbourne, Australia, employs 32,000 people, and delivers its lifesaving therapies to people in more than 100 countries.

To learn more about CSL, CSL Behring, CSL Seqirus and CSL Vifor visit https://www.csl.com/ and CSL Plasma at https://www.cslplasma.com/.

Our Benefits

For more information on CSL benefits visit How CSL Supports Your Well-being | CSL.

You Belong at CSL

At CSL, Inclusion and Belonging is at the core of our mission and who we are. It fuels our innovation day in and day out. By celebrating our differences and creating a culture of curiosity and empathy, we are able to better understand and connect with our patients and donors, foster strong relationships with our stakeholders, and sustain a diverse workforce that will move our company and industry into the future.

To learn more about inclusion and belonging visit https://www.csl.com/careers/inclusion-and-belonging

Equal Opportunity Employer

CSL is an Equal Opportunity Employer. If you are an individual with a disability and need a reasonable accommodation for any part of the application process, please visit https://www.csl.com/accessibility-statement.