About this role
About Synolo Therapeutics:
Synolo Therapeutics, an early-stage biotechnology company launched by RA Ventures, is pioneering the development of precision-targeted immunotherapies for cancer. Powered by computational protein design and proprietary technologies that yield biological data sets at unprecedented scale and resolution, we are building a pipeline of first-in-class multi-specific biologics with novel functionalities. Synolo was founded by pioneers in the field of protein design and engineering, synthetic biology, DNA sequencing, immunology, and biologics drug discovery and development.
About RA Capital:
RA Capital Management funds and builds healthcare and life science companies using an evidence-based investment approach informed by TechAtlas, a think tank within RA Capital which analyzes scientific and clinical data from academic literature and industry sources to anticipate how breakthroughs might impact industry stakeholders, physicians, patients, and policymakers. TechAtlas' analyses are captured in a unique collection of competitive landscapes, or ‘maps’, that identify competitive therapeutics, diagnostics, research tools, and/or technological capabilities in a given area.
About the Role
Synolo Therapeutics is seeking a highly strategic Principal Scientist, In Vivo Immunology to lead the design and execution of in vivo pharmacology strategies across our multispecific biologics pipeline.
This individual will serve as the in vivo immunology subject matter expert, responsible for architecting disease models, defining study endpoints, driving translational hypotheses, and ensuring rigorous, data-driven decision-making across programs. As a key scientific leader, you will work closely with internal stakeholders and external partners to advance molecules from discovery through preclinical development.
This is a high-impact role for a scientist who thrives in a fast-paced startup environment and is motivated by building scientific capabilities that directly shape pipeline strategy.
About Synolo Therapeutics
Cell therapy company developing engineered T cells with synthetic biology for solid tumors. Based in Cambridge, MA.
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PostedMar 11, 2026
LocationCambridge, MA
Work typeOnsite
DepartmentImmuno Oncology
SenioritySenior
CountryUnited States
Synolo Therapeutics
Cell therapy company developing engineered T cells with synthetic biology for solid tumors. Based in Cambridge, MA.
View all 3 open jobs at Synolo Therapeutics