Raziskovalec ekspert I / Senior Scientist I

Salary Range:

€27,160.00 - €50,440.00

 

Job Description Summary

#LI-Hybrid
Location: Menges, Slovenia

Role Purpose:
Our R&D unit in Mengeš is looking for a motivated scientist in field of Downstream Processing (DSP) to join us in Mengeš and help us develop a diverse portfolio of biotherapeutic modalities.

As a Senior Scientist you must demonstrate a broad and in-depth knowledge of technologies in recombinant protein production and purification to evaluate the developability of various biologics modalities covered by Novartis Biomedical Research and Development units, ranging from traditional antibodies to advanced biologics formats and mixed modalities, ensuring quality of material delivered and eventually enabling lead candidate selection.
We offer a stimulating work environment, ample opportunities for growth and development, and the chance to make a significant impact on the future of medicine. If you are a motivated and talented scientist with a passion for biomedical research, we invite you to apply and become a part of our dynamic team at Novartis.

Naša R&D enota v Mengšu išče motiviranega raziskovalca na področju izolacij bioloških učinkovin (DSP), ki se nam bo pridružil v Mengšu in nam pomagal razvijati raznolik portfelj bioterapevtikov.


Kot Raziskovalec ekspert morate izkazovati široko in poglobljeno poznavanje tehnologij za proizvodnjo in čiščenje rekombinantnih proteinov, da boste lahko ocenili razvojni potencial različnih bioloških terapevtskih kandidatov, ki jih pokrivajo enote Novartis Biomedicinske raziskave in Razvoj, od tradicionalnih protiteles do naprednih bioloških formatov in mešanih modalnosti, pri čemer boste zagotavljali kakovost dostavljenega materiala ter na koncu omogočili izbor vodilnega kandidata.

Ponujamo spodbudno delovno okolje, številne priložnosti za rast in razvoj ter možnost pomembnega vpliva na prihodnost medicine. Če ste motiviran in nadarjen znanstvenik s strastjo do biomedicinskih raziskav, vas vabimo, da se prijavite in postanete del naše dinamične ekipe v Novartisu.

 

Job Description

Key responsibilities

• Downstream purification of recombinantly expressed proteins from suspension CHO culture from small to large scale (up to 200L).
• Design, plan, perform and complete lab and preparative scale purifications of antibodies antibody derivatives and other novel protein formats using state-of-the-art equipment
• As DSP lead plan, manage and coordinate protein productions across multiple projects in cross-discipline project teams 
• Independently generate hypotheses, design and execute follow-up experiments, and troubleshoot issues
• Lead technology projects for protein purification and conjugation in close collaboration with related line functions; incorporate latest technologies and knowledge into research activities and ongoing projects 
• Author lab procedures and technology evaluations
• Accurately and timely process samples, contribute to result interpretation and prepare summary presentations and timely document all data in electronic lab journal and databases 
• Actively undertake organizational responsibilities in lab organization and shipments, including maintaining equipment and implementation of new equpiment

Minimum Requirements - What you will bring to the role:

• MSc University degree in chemistry, biochemistry, chemical technology or other relevant discipline with at least 3 years of relevant work experience in industry, or BSc University degree in chemistry, biochemistry, chemical technology or other relevant discipline with at least 6 years of relevant work experience in industry
• Good theroretical and strong practical background in Downstream Processing of monoclonal and multispecific antibodies, including several years of hands-on experience with Aekta liquid chromatography, filtration, and centrifugation technologies
• Strong experience in experimental design and data analysis  
• High learning ability to acquire expertise in new technologies and technical equipment
• Proven experience in successfully prioritizing and keeping timelines
• Open and proactive communication, ability to interact with various stakeholders
• Reliable and flexible team player, accustomed to sharing tasks and projects
• Fluency in English (oral/written)

Desirable skills:

• Solid experience in one of the neighboring disciplines (Upstream Processing and/or Phys-Chem protein analytics)

Global pharmaceutical company focused on innovative medicines in oncology, immunology, and neuroscience. Headquartered in Basel, Switzerland.

novartis.com