Associate Director, Translational Physician-Scientist

Overview The Research Department at Alnylam is seeking a passionate and creative physician-scientist to join the Translational Research Group to play a key role in guiding the discovery, validation, and prioritization of new therapeutic targets. You will join a highly collaborative team of translational biologists, proteomics scientists, metabolomics scientists, physician-scientists, and data scientists to enhance the translation of basic discoveries in biology and human genetics to new medicines. Our Research Department is a fast-paced and dynamic environment where promising new ideas rapidly progress to the clinic. This is an excellent opportunity for academic physician-scientists looking to transition into drug development. Working on-site in Cambridge, MA, you will collaborate across our Research, Early Development, and Clinical Research teams to drive programs from lead target identification through early-stage (Ph1/2) clinical trials. Key Attributes and Responsibilities * Integrate knowledge of medicine with insights from human data including genetics, natural history studies, and clinical trials to generate and vet novel therapeutic hypotheses. * Play a leading role in identifying early translational and clinical key opinion leaders, driving scientific discussions, and building external relationships that support human sample sourcing and translational modeling. * Evaluate the scientific rationale and clinical feasibility of indications for new targets, using medical knowledge to guide preclinical and translational strategy. * Lead early biomarker strategy across multiple programs, collaborating with in-house data scientists, molecular biologists, and computational experts to align biomarker discovery with emerging clinical plans. * Represent Translational Research across preclinical and clinical development, from lead target identification through Phase 2 clinical trials, by engaging key stakeholders, presenting to leadership, and contributing to trial design and biomarker discovery and development. Qualifications * Proven track record of putting basic sciences questions in a translational/clinical context. * MD or MD/PhD with a strong foundation in a subspeciality with sufficient exposure to a breadth of rare and common diseases. * Capacity to quickly synthesize the clinical trial landscape and contribute to trial design (prior industry experience is highly valued, but not required for a candidate with strong scientific fundamentals). * Exceptional scientific communication skills with a proven ability to draft high-impact manuscripts, present to leadership, and independently balance long-term strategic projects with time-sensitive, fast-paced requests. * Experience in academia or industry with human genetics, biomarker discovery, or therapeutic development. Familiarity with computational biology, bioinformatics, or working closely with statistical geneticists is a strong plus. #LI-JR1 U.S. Pay Range $202,300.00 - $273,700.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Biopharmaceutical company pioneering RNA interference (RNAi) therapeutics for rare genetic, cardiometabolic, and CNS diseases. Headquartered in Cambridge, MA.

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