Cyber Defense Principal Engineer

Define and execute the long-term strategy and technical roadmap for Alnylam's cyber defense capabilities. Architect and scale core security platforms, including SIEM/SOAR, security data pipelines, automation frameworks, and detection infrastructure. Lead enterprise detection engineering, delivering advanced analytics and risk-based alerting across cloud, endpoint, identity, network, and SaaS environments. Build and integrate a unified cyber defense platform to enhance visibility, automation, and enterprise resilience. Establish scalable security standards, architectures, and operating principles across Cyber Defense and enterprise teams. Drive an engineering-first approach to detection and response, leveraging automation, AI-enabled workflows, and data-driven decision making. Serve as a senior technical advisor to leadership on cyber defense strategy, complex incident response, and enterprise risk. 10+ years of experience across core cyber defense disciplines (e.g., security engineering, detection engineering, threat hunting, incident response, vulnerability management, offensive security) Strong programming and automation skills (e.g., Python, Go), with experience building custom security tooling, integrations, and detections Proven experience leading large-scale SIEM migrations or enterprise security platform transformations Deep expertise across modern security technologies (e.g., SIEM, SOAR, EDR/XDR, threat intelligence platforms, cloud security, and security data platforms) Hands-on experience applying AI/ML and automation to improve threat detection, investigation workflows, and incident response Advanced detection engineering capabilities, including behavioral analytics, threat hunting, and frameworks such as MITRE ATT&CK Experience designing or supporting insider threat and advanced monitoring programs Strong knowledge of vulnerability management, exposure reduction, and risk-based prioritization Excellent communication and influencing skills, with the ability to partner across engineering, infrastructure, legal, compliance, and business leadership teams Experience operating in complex, global enterprise environments

Biopharmaceutical company pioneering RNA interference (RNAi) therapeutics for rare genetic, cardiometabolic, and CNS diseases. Headquartered in Cambridge, MA.

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