VP, Program Management

Overview: The Vice President, Program Management will play a critical role in advancing programs from Research through Development, Commercialization, and lifecycle management. Program Managers at Alnylam partner with Program Leaders and cross-functional teams to drive strategic execution, manage timelines and key deliverables, identify risks and opportunities, and ensure successful achievement of program milestones and stage gates. The Vice President, Program Management reports to the Head of Pipeline Delivery and leads the global Program Management organization supporting Alnylam's Research, Development, and Commercial portfolios. This leader will drive operational excellence by establishing best practices, standardizing tools and processes, and ensuring consistent, best-in-class program support across the portfolio. The successful candidate will bring deep program management expertise, a strong understanding of the drug development lifecycle, and a proven ability to build high-performing teams. They will provide strategic leadership to optimize portfolio and cross-functional team performance, while fostering a culture of accountability, agility, and continuous improvement. This role requires the ability to balance multiple priorities, navigate complexity, and develop scalable solutions that support Alnylam's evolving business needs. Key Responsibilities: * Lead, develop and mentor the group of Program Management professionals spanning research, development, and commercial parts of the business while also being a steward of Alnylam’s core values: Purposeful Urgency, Passion for Excellence, Commitment to People, being Fiercely Innovative, and promoting Open Culture * Leverage extensive drug development experience and strong interpersonal skills to drive operational excellence and establish the value of an effective Program Management function to the company’s success * Establish a proactive and out-reaching approach across Program Leads, department heads and executive team to facilitate communication channels and ensure all programs operational efficiency * In collaboration with department heads and Program Leads, develop an integrated resource plan for each program; conduct analyses, identify gaps, and make recommendations on resource allocation across programs * Assess current Program Management organizational design, infrastructure and work tools to make recommendations on proficiency, standardization and investments required. * Lead and influence within a global matrixed organization and impact decision-making at the highest levels of the organization, while aligning across corporate and business lines * Contribute to, enable and facilitate the development of Program specific annual and long- range corporate objectives, ensuring regular, audience-appropriate communications on status, progress, risks and mitigation efforts to facilitate appropriate discussions * Strategize with program team leadership and other necessary stakeholders to formulate positions and drive alignment process, including in key processes such as the Long-Range Plan and Budget Setting process * Drive overall improvement of and operational consistency across the Program Management team through skill building, best practice development, and applying consistent frameworks across the group * Partner with Alliance Management to coordinate activities and business requirements in support of partnered programs * Provide expertise on organizational effectiveness initiatives including alignment of processes, tools, and technologies that aid in portfolio management across the organization Qualifications: * Minimum of 15+ years’ experience in pharmaceutical or biotechnology industry program management, including work on pre-clinical and clinical stage programs * Bachelor’s degree in sciences or related field required, with an Advanced degree (PhD or MBA) * Demonstrated proficiency in program management tools (e.g., Smartsheet, Microsoft Project) and methodology. Knowledge and ability to improve project management tools and skillset through best practices * Strong leadership, problem solving, management and communication skills * Ability to understand program objectives and risks across the entire development and commercialization landscape, so as to provide effective guidance and training to program managers * Excellent interpersonal skills and ability to work effectively with multiple functions * Ability to lead and influence cross functional teams * Self-starter who can manage through ambiguity, learn on the fly, handle multiple priorities, and perform job responsibilities accurately while working in a high energy, deadline-driven, and fast-paced environment * Possess the ability to generate enthusiasm, the ability to quickly gain trust and respect of peers and senior leadership, and have a track record of successfully driving results through strong partnership with others * Sound judgment and discretion in sensitive matters. * Ability to influence without authority. * Thrives in highly entrepreneurial biotech environment and embraces Alnylam’s culture of science, passion and urgency. * Intellectual curiosity, adaptability, and desire to learn and grow to meet the evolving needs of the organization. #LI-HM1 U.S. Pay Range $318,800.00 - $431,200.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Biopharmaceutical company pioneering RNA interference (RNAi) therapeutics for rare genetic, cardiometabolic, and CNS diseases. Headquartered in Cambridge, MA.

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