Sr Machine Learning Engineer

Career Category

Job Description

• Job Description

  We are seeking a Sr Machine Learning Engineer—Amgen’s most senior individual-contributor authority on building and scaling end-to-end machine-learning and generative-AI platforms. Sitting at the intersection of engineering excellence and data-science enablement, you will design the core services, infrastructure and governance controls that allow hundreds of practitioners to prototype, deploy and monitor models—classical ML, deep learning and LLMs—securely and cost-effectively.

  Acting as a “player-coach,” you will establish platform strategy, define technical standards, and partner with DevOps, Security, Compliance and Product teams to deliver a frictionless, enterprise-grade AI developer experience.

  Roles & Responsibilities:

  • Engineer end-to-end ML pipelines—data ingestion, feature engineering, training, hyper-parameter optimization, evaluation, registration and automated promotion—using Kubeflow, SageMaker Pipelines, Open AI SDK or equivalent MLOps stacks.

  • Harden research code into production-grade micro-services, packaging models in Docker/Kubernetes and exposing secure REST, gRPC or event-driven APIs for consumption by downstream applications.

  • Build and maintain full-stack AI applications by integrating model services with lightweight UI components, workflow engines or business-logic layers so insights reach users with sub-second latency.

  • Optimize performance and cost at scale—selecting appropriate algorithms (gradient-boosted trees, transformers, time-series models, classical statistics), applying quantization/pruning, and tuning GPU/CPU auto-scaling policies to meet strict SLA targets.

  • Instrument comprehensive observability—real-time metrics, distributed tracing, drift & bias detection and user-behavior analytics—enabling rapid diagnosis and continuous improvement of live models and applications.

  • Embed security and responsible-AI controls (data encryption, access policies, lineage tracking, explainability and bias monitoring) in partnership with Security, Privacy and Compliance teams.

  • Contribute reusable platform components—feature stores, model registries, experiment-tracking libraries—and evangelize best practices that raise engineering velocity across squads.

  • Perform exploratory data analysis and feature ideation on complex, high-dimensional datasets to inform algorithm selection and ensure model robustness.

  • Partner with data scientists to prototype and benchmark new algorithms, offering guidance on scalability trade-offs and production-readiness while co-owning model-performance KPIs.

  Must-Have Skills:

  • 3-5 years in AI/ML and enterprise software.

  • Comprehensive command of machine-learning algorithms—regression, tree-based ensembles, clustering, dimensionality reduction, time-series models, deep-learning architectures (CNNs, RNNs, transformers) and modern LLM/RAG techniques—with the judgment to choose, tune and operationalise the right method for a given business problem.

  • Proven track record selecting and integrating AI SaaS/PaaS offerings and building custom ML services at scale.

  • Expert knowledge of GenAI tooling: vector databases, RAG pipelines, prompt-engineering DSLs and agent frameworks (e.g., LangChain, Semantic Kernel).

  • Proficiency in Python and Java; containerisation (Docker/K8s); cloud (AWS, Azure or GCP) and modern DevOps/MLOps (GitHub Actions, Bedrock/SageMaker Pipelines).

  • Strong business-case skills—able to model TCO vs. NPV and present trade-offs to executives.

  • Exceptional stakeholder management; can translate complex technical concepts into concise, outcome-oriented narratives.

• Additional Job Description

  Additional Job Description

Leading biotechnology company focused on oncology, cardiovascular, bone health, and inflammation therapies. Based in Thousand Oaks, CA.

amgen.com